School Seminars and Colloquia

Colloquium: Statistical analysis of genetic data to find genes involved in disease


by Dr Melanie Bahlo

Institution: Walter and Eliza Hall Institute of Medical Research
Date: Tue 19th May 2009
Time: 12:00 PM
Location: Russell Love Theatre, Richard Berry Bldg, The Uni of Melb

Abstract: Despite the generation of vast amounts of genetic data in public genomics
such as the Human Genome Project the function of many genes remains a
mystery. Families which
are carrying a genetic disease can have their faulty gene identified
through a combination of
statistical analysis and benchwork. This not only provides a genetic test
for the family but can
also give valuable genetic information about the function of the gene.
Statistical analysis is used to identify a genomic segment that is likely
to harbour the mutated gene. I will illustrate how and when this approach
works and compare it to the current, in vogue, approach of genome wide
association analysis using case control studies. I will also discuss the
way the genetic data is measured (SNP chips) and how one can use the same
data for the interpretation of DNA copy number which are deviations to the
usual 2 copies of DNA that we all have.

For More Information: Contact Paul Pearce ( or Paul Norbury (

Colloquium Website