School Seminars and Colloquia

Mathematical Modelling of Layering within Nature

Completion Seminar

by James Caffrey


Institution: University of Melbourne
Date: Tue 14th February 2012
Time: 1:00 PM
Location: Richard Berry Building - Russell Love Theatre

Abstract: The creation of layers within the cortex of the mammalian brain has often
been of interest to researchers in developmental biology. Experiments on
mice have found a counter-intuitive layering sequence. The layers are
formed in an inside-out arrangement, with the deepest layers formed first
and the outermost last. It is believed that the glycoprotein reelin is
linked to the mechanisms behind layering. It is observed in the reeler
mutant, where this glycoprotein is absent, that the layer arrangement is
reversed. This has led to a number of mechanisms being proposed for how
reelin may affect the neurons that form the cortical layers. No conclusive
theory has of yet been established.

Mathematical modelling provides an elegant method to evaluate the
feasibility of different layering mechanisms. Within this talk, various
models for layered structures will be discussed. Both continuum and
discrete models will be discussed. After presenting the base models, I
will discuss the general insights our modelling can provide for cortical
layering.

For More Information: contact Guoqi Qian, email: g.qian@ms.unimelb.edu.au