School Seminars and Colloquia

Short oligonucleotide microarrays: a low-level viewpoint

Statistics Seminar

by Terry Speed


Institution: Walter and Eliza Hall Institute
Date: Thu 6th September 2007
Time: 12:00 PM
Location: Room 213, Richard Berry Building, University of Melbourne

Abstract: Since their appearance about a decade ago, microarrays have been
adapted to do much more than provide a crude quantitation of mRNA
abundance. Originally conceived as a high-throughput DNA sequencing
technology, short oligonucleotide arrays first made their mark in
expression studies. They continue to make novel contributions to that
area, in the form of tiling arrays, but are now also being used to
identify protein binding sites, to genotype DNA samples, to study
alternative splicing, and other tasks, including DNA sequencing, all on a genome-wide scale. I have been involved in several of these activities
at what I call the low level, that is, starting with probe-level data,
converting it into useable measurements and doing very basic things. The
primary challenges are statistical. I'll start by briefly outlining what
we do. In so doing, I'll touch on some of the interesting experiments
done by our collaborators, and show some of the possibilities of these
technologies.

For More Information: Dr Owen Jones O.D.Jones@ms.unimelb.edu.au