School Seminars and Colloquia

Computational modelling of tissue homeostasis and injury

Continuum Modelling Seminar

by Dr Bruce Gardiner

Institution: Biomedical Engineering, The University of Melbourne
Date: Mon 7th April 2008
Time: 4:15 PM
Location: Old Geology - Theatre 2, The University of Melbourne

Abstract: There is a growing appreciation that biological tissues respond not only to their chemical environment, but also to their physical environment. For example, bone density changes according to hormone levels (e.g. estrogen) and load (e.g. weight-bearing exercises). Endothelial cells lining arteries respond to inflammatory cytokines (e.g. TNF-alpha) but align themselves with fluid flow (e.g. fluid shear stress). Tissue engineered heart valves require intercellular communication through membrane molecules and diffusible molecules as well as being exposed to pulsatile flow for proper development. The complex interaction between chemical and physical factors governing cell response, and therefore tissue health, provides strong impetus for the involvement of mathematical/computational modelling to understand these systems. The talk will provide a brief overview of my research interests in this area, but will focus on two research topics (i) cartilage homeostasis through feedback mechanisms (cartilage is a tissue that survives in a hostile mechanical environment through multiple feedback mechanisms to maintain tissue homeostasis. I will describe a new computational model that includes growth factor and deformation mediated matrix biosynthesis in articular cartilage), and (ii) the biophysical processes controlling oxygen concentrations in the mammalian kidney

For More Information: Professor Kerry Anne Landman