School Seminars and Colloquia

(1) T cell development in the thymus: spatial dependence (2) Modeling a Tissue Engineering Application: Cell Transplantation

School Seminar

by (1) Daniel Mentiplay (2) Rebecca Chisholm


Institution: The University of Melbourne
Date: Mon 11th August 2008
Time: 4:15 PM
Location: Architecture Sisalkraft Theatre, The University of Melbourne

Abstract: (1) T cell development in the thymus: spatial dependence, by Daniel Mentiplay

The thymus is the gland responsible for production of T cells in the body.
Stem cells from the bone marrow enter via the vasculature and undergo a
process of differentiation and selection, which is position dependent.
Approximately only 5% are selected to become mature T cells. A simple
linear model is proposed to investigate the positional bias in
differentiation.





(2) Modeling a Tissue Engineering Application: Cell Transplantation, by Rebecca Chisholm


Cell Transplantation is a method that involves seeding a scaffold with cells and cell growth related molecules before culturing and implanting it into an area of the body which requires accelerated tissue growth. The model to be discussed relates to the initial stages of the procedure where the scaffold is seeded with cells and then cultured. A discrete model of cells proliferating in a one-dimensional scaffold has been developed and it is our aim to determine the analytical formulae that describe the model's results.


For More Information: Kerry Landman K.Landman@ms.unimelb.edu.au