A Stochastic Model of Coupled Enzymatic Processing
by Professor Ruth Williams
Abstract: A major challenge for systems biology is to deduce â€¨the molecular interactions that underlie correlationsâ€¨ observed between concentrations of different intracellular molecules.
While direct explanations such â€¨as coupled transcription or direct protein-protein â€¨interactions are often considered, potential indirectâ€¨ sources of coupling have received much less attention.â€¨
In this talk, I will report on an investigation,â€¨ involving both a stochastic model and related experiments,â€¨ of how correlations can arise generically fromâ€¨ such an indirect coupling
mechanism involving theâ€¨ processing of multiple protein species by a commonâ€¨ enzyme.â€¨â€¨
Based on joint work with Natalie Cookson, Tal Danino, Jeffâ€¨Hasty, Will Mather, Octavio Mondragon-Palomino,â€¨ Lev Tsimring.
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